Publications

Preface to the special issue on oral regional immune mechanisms and systemic homeostasis

Cao D, Fang J, Wan G*, Wang Z*.

Oral Sci Homeost Med. 2026 Jun; 2(2): 9610062·2026·DOI

Wan Lab authors: 万国辉

Engineering bacterial nanosyringes for regional immune recalibration at the oral barrier

Wan AH, Liang H, Yan S, Xiao M, Liu R, Wan G*

Oral Sci Homeost Med. 2026 May; 2(2): 9610055.·2026·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 刘若年, 肖敏

Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity.

Deng Y#, Liang H#, Wan AH#, Liu C#, Yan S#, Li J, Xiao M, Zhou Q, Liu R, Zhang Z, Zhang H, Cheng H, Fu C, Yao Q, Fang J, Neumann S, Wang Q, Huang J*, Wang Z*, Wan G*.

Cell Rep Med. 2026 Jun 16;7(6):102801.·2026·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 刘若年, 肖敏, 张孜彤, 姚琪俊, 付程源, 程慧雅, 周秋生, 邓媛, 刘础维, 李佳蕊, 张贺腾

TeroACT: A terpenoid bioactivity landscape and discovery platform.

Shen X#, Yan S#, Kang X, Xu K, Jian Y, Zeng T, Wan G*, Wu R*.

Acta Pharm Sin B. 2026 Mar;16(3):1233-1249.·2026·DOI

Wan Lab authors: 万国辉, 严时佳

HNRNPA2B1 Orchestrates Immune Evasion in Colorectal Cancer by Rewiring Tumor-Immune Cell Interactions and Suppressing CD8+ T-cell Infiltration.

Liu C, Liang H, Wang P, Xiao M, Zheng Y, Yan S, Deng Y, Liu R, Wan AH, Wang Z*, Lu X*, Song W*, He W*, Wan G*.

Cancer Immunol Res. 2026 Jan 8;14(1):60-76.·2026·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 刘若年, 肖敏, 邓媛

Non-stoichiometric Sodium Chloride Reprograms Ionic Homeostasis to Enhance Antitumor Immunity.

Wang C#, Deng Y#, Liang H#, Wan AH#, Yan S, Xiao M, Liu C, Fang J, Wang Z*, Wan G*.

MedComm (2020). 2025 Nov 29;6(12):e70534.·2025·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 肖敏, 邓媛, 刘础维

Proviral Integration Site for Moloney Murine Leukemia Virus 2 Suppresses Fibronectin 1 to Drive Adhesion Loss and Epithelial-Mesenchymal Transition in Multiple Myeloma.

Mai J#, Liang H#, Wan AH#, Xiao M#, Zhang H, Deng Y, Yan S, Wan G*, Zheng Y*.

ACS Pharmacol Transl Sci. 2025 Oct 27;8(11):3835-3843.·2025·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 肖敏, 邓媛, 麦俊娜, 张贺腾

Machine learning-assisted tacrolimus dose optimization in childhood- onset systemic lupus erythematosus through population pharmacokinetic modeling.

Liang H#, Xuan Q#, Liu C#, Wan A#, You N, Xiao M, Zhang H, Han M, Wan G*.

Comput Biol Med. 2025 Sep;196(Pt B):110782.·2025·DOI

Wan Lab authors: 万国辉, 梁衡, 肖敏, 刘础维, 游楠, 张贺腾

Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach.

Liu C#, Liang H#, Wan AH#, Xiao M#, Sun L#, Yu Y, Yan S, Deng Y, Liu R, Fang J, Wang Z*, He W*, Wan G*.

Nat Commun. 2025 Jan 18;16(1):798.·2025·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 刘若年, 肖敏, 孙蕾, 邓媛, 刘础维

TarIKGC: A Target Identification Tool Using Semantics-Enhanced Knowledge Graph Completion with Application to CDK2 Inhibitor Discovery.

Shen X, Yan S, Zeng T, Xia F, Jiang D, Wan G, Cao D*, Wu R*.

J Med Chem. 2025 Jan 23;68(2):1793-1809.·2025·DOI

Wan Lab authors: 万国辉, 严时佳

Integrating genome-wide CRISPR screens and in silico drug profiling for targeted antidote development.

Wang B, Xu Y, Wan AH, Wan G*, Wang QP*.

Nat Protoc. 2024 Sep;19(9):2739-2770.·2024·DOI

Wan Lab authors: 万国辉, 王倍

Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1.

Hu Z, Li M, Chen Y, Chen L, Han Y, Chen C, Lu X, You N, Lou Y, Huang Y, Huo Z, Liu C, Liang C, Liu S, Deng K, Chen L, Chen S, Wan G, Wu X, Fu Y*, Xu A*.

Sci China Life Sci. 2024 Jun;67(6):1212-1225.·2024·DOI

Wan Lab authors: 万国辉, 游楠, 娄雅文

Formyl peptide enhances cancer immunotherapy by activating antitumoral neutrophils, and T cells.

Sun H, Li S, Wang Q, Luo C, Zhong L, Wan G, Li Z, Zhao G, Bu X, Zeng M*, Feng G*.

Biomed Pharmacother. 2024 Jun;175:116670.·2024·DOI

Wan Lab authors: 万国辉

Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin-Induced Liver Injury.

Zhao T, Zhong G, Wang Y, Cao R, Song S, Li Y, Wan G, Sun H, Huang M*, Bi H*, Jiang Y*.

Adv Sci (Weinh). 2024 May;11(19):e2308771.·2024·DOI

Wan Lab authors: 万国辉

A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance.

Sun L, Wan AH, Yan S, Liu R, Li J, Zhou Z, Wu R, Chen D, Bu X, Ou J, Li K, Lu X, Wan G*, Ke Z*.

Acta Pharm Sin B. 2024 Jan;14(1):223-240.·2024·DOI

Wan Lab authors: 万国辉, 严时佳, 刘若年, 孙蕾, 吴瑞瑞, 李佳蕊

Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.

Sun L, Liu R, Wu ZJ, Liu ZY, Wan AH, Yan S, Liu C, Liang H, Xiao M, You N, Lou Y, Deng Y, Bu X, Chen D, Huang J, Zhang X, Kuang DM, Wan G*.

Gastroenterology. 2024 Mar;166(3):466-482.·2024·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 刘若年, 肖敏, 孙蕾, 邓媛, 刘础维, 游楠, 娄雅文

The role of γ-aminobutyric acid in tumor immunity

Qiao L, Xiao M, Jiang J, Wan G*.

Acta Pharm Sin. 2023, 58(8): 2120-2129·2023·DOI

Wan Lab authors: 万国辉, 肖敏

Biological informed graph neural network for tumor mutation burden prediction and immunotherapy-related pathway analysis in gastric cancer.

Liu C#, Wan AH#, Liang H#, Sun L, Li J, Yang R, Li Q, Wu R, Hu K, Yang Y, Cai S*, Wan G*, He W*.

Comput Struct Biotechnol J. 2023 Sep 22;21:4540-4551.·2023·DOI

Wan Lab authors: 万国辉, 梁衡, 孙蕾, 刘础维, 李佳蕊

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.

Yue X, Liu T, Wang X, Wu W, Wen G, Yi Y, Wu J, Wang Z, Zhan W, Wu R, Meng Y, Cao Z, Le L, Qiu W, Zhang X, Li Z, Chen Y, Wan G, Bu X*, Peng Z*, Liu RY*.

Acta Pharm Sin B. 2023 Aug;13(8):3382-3399.·2023·DOI

Wan Lab authors: 万国辉

A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy.

Zhou Z, Van der Jeught K, Li Y, Sharma S, Yu T, Moulana I, Liu S, Wan J, Territo PR, Opyrchal M, Zhang X*, Wan G*, Lu X*.

Adv Sci (Weinh). 2023 Aug;10(23):e2300548.·2023·DOI

Wan Lab authors: 万国辉

Pantethine Ameliorates Recognition Impairment in a Mouse Model of Alzheimer’s Disease by Modulating Cholesterol Content and Intestinal Flora Species.

Chen J, Li Y, Chen M, Liu X, Chen J, Li X, Wang C, Wan G, Tian J*.

Mol Nutr Food Res. 2023 Aug;67(15):e2200799.·2023·DOI

Wan Lab authors: 万国辉

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity.

Wang B#, Wan AH#, Xu Y#, Zhang RX, Zhao BC, Zhao XY, Shi YC, Zhang X, Xue Y, Luo Y, Deng Y, Neely GG, Wan G*, Wang QP*.

Nat Commun. 2023 May 16;14(1):2241.·2023·DOI

Wan Lab authors: 万国辉, 王倍

Metabolic Reprogramming Driven by IGF2BP3 Promotes Acquired Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.

Lin Z, Li J, Zhang J, Feng W, Lu J, Ma X, Ding W, Ouyang S, Lu J, Yue P, Wan G, Liu P*, Zhang X*.

Cancer Res. 2023 Jul 5;83(13):2187-2207.·2023·DOI

Wan Lab authors: 万国辉, 林子又

Selenium Nanoparticles Based on Morinda officinalis Polysaccharides: Characterization, Anti-Cancer Activities, and Immune-Enhancing Activities Evaluation In Vitro.

Yao M, Deng Y, Zhao Z, Yang D, Wan G, Xu X*.

Molecules. 2023 Mar 7;28(6):2426.·2023·DOI

Wan Lab authors: 万国辉, 邓媛

N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.

Lin Z, Wan AH, Sun L, Liang H, Niu Y, Deng Y, Yan S, Wang QP, Bu X, Zhang X, Hu K*, Wan G*, He W*.

Mol Ther. 2023 Feb 1;31(2):517-534.·2023·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 牛艺, 林子又, 孙蕾, 邓媛

Oxidative Stress Induces Apoptosis and Inflammation in in vitro Dry Eye Models Which Can Be Reversed by Antioxidant SkQ1

Tang D, Xiong Y, Gao C, Yang B, Petrov A, Perekhvatova N, Skulachev M, Xue Q, Fang H, Wan G, Ngiam M

Invest Ophthalmol Vis Sci. 2022, 63: 3643 - A0208·2022·DOI

Wan Lab authors: 万国辉, 唐道琪

Tryptophan and tumor immunity

Zhang C, Yan S, Wan G*.

Acta Pharm Sin. 2022, 57(9): 2580-2589·2022·DOI

Wan Lab authors: 万国辉, 严时佳

The immunomodulatory effect of lactic acid within the tumor microenvironment

Ge W, Yan S, Wan G*.

Acta Pharm Sin. 2022, 57(9): 2570-2579·2022·DOI

Wan Lab authors: 万国辉, 严时佳

Application and prospect of circulating tumor cell in colorectal cancer immunotherapy

Wan AH, Li J, Xin W*, Wan G*.

Acta Pharm Sin. 2022, 57(9): 2590-2600·2022·DOI

Wan Lab authors: 万国辉, 李佳蕊

The application of genome-wide CRISPR-Cas9 screens to dissect the molecular mechanisms of toxins.

Wang B, Chen JZ, Luo XQ, Wan GH, Tang YL, Wang QP*.

Comput Struct Biotechnol J. 2022 Sep 13;20:5076-5084.·2022·DOI

Wan Lab authors: 万国辉

FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy.

Guan S, Chen X, Chen Y, Wan G, Su Q, Liang H, Yang Y, Fang W, Huang Y, Zhao H, Zhuang W, Liu S, Wang F, Feng W, Zhang X, Huang M*, Wang X*, Zhang L*.

Acta Pharm Sin B. 2022 Sep;12(9):3639-3649.·2022·DOI

Wan Lab authors: 万国辉

RNA and RNA Derivatives: Light and Dark Sides in Cancer Immunotherapy.

Deng Y#, Xiao M#, Wan AH#, Li J, Sun L, Liang H, Wang QP, Yin S, Bu X, Wan G*.

Antioxid Redox Signal. 2022 Dec;37(16-18):1266-1290.·2022·DOI

Wan Lab authors: 万国辉, 梁衡, 肖敏, 孙蕾, 邓媛, 李佳蕊

Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.

Song Z, Huang YY, Hou KQ, Liu L, Zhou F, Huang Y, Wan G, Luo HB*, Xiong XF*.

J Med Chem. 2022 Mar 10;65(5):4238-4254.·2022·DOI

Wan Lab authors: 万国辉

Identification of 2-Benzylidene-tetralone Derivatives as Highly Potent and Reversible Firefly Luciferase Inhibitors.

Li Y, Jin C, Xu H, Wu W, Wang Y, Wu J, Liu T, Wan G, Yue X, Bu X*.

ACS Med Chem Lett. 2022 Jan 20;13(2):304-311.·2022·DOI

Wan Lab authors: 万国辉

Measurement of Circulating Tumor Cells to Track Hepatocellular Carcinoma Progression After Liver Transplantation-Case Report.

Deng Y, Sun L, Liang H, Cui B, Cui C, Zhao D, Wan A*, Wan G*.

Front Oncol. 2021 Oct 20;11:760765.·2021·DOI

Wan Lab authors: 万国辉, 梁衡, 孙蕾, 邓媛

Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.

Niu Y, Lin Z, Wan A, Sun L, Yan S, Liang H, Zhan S, Chen D, Bu X, Liu P, Chen C, He W, Lu X, Wan G*.

Hepatology. 2021 Sep;74(3):1461-1479.·2021·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 牛艺, 林子又, 孙蕾, 詹偲悦

Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers.

Li Q, He W*, Wan G*.

Front Oncol. 2021 Feb 1;10:586789.·2021·DOI

Wan Lab authors: 万国辉

Tumor-associated macrophages in immunotherapy.

Yan S, Wan G*.

FEBS J. 2021 Nov;288(21):6174-6186.·2021·DOI

Wan Lab authors: 万国辉, 严时佳

RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer.

Sun L#, Wan A#, Zhou Z, Chen D, Liang H, Liu C, Yan S, Niu Y, Lin Z, Zhan S, Wang S, Bu X, He W, Lu X*, Xu A*, Wan G*.

Gut. 2021 Sep;70(9):1698-1712.·2021·DOI

Wan Lab authors: 万国辉, 梁衡, 严时佳, 牛艺, 林子又, 孙蕾, 詹偲悦

Hypoxia⁃induced HIF⁃1α down⁃regulates FUT4 expression under hypoxia in colon cancer via inducing hsa⁃ miRNA⁃23a⁃3p

He W, Li Q, Yan S, Wan G*.

J Pract Med. 2020, 36(8): 1035-1040·2020·DOI

Wan Lab authors: 万国辉, 严时佳

Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand 1 Inhibitor as Immune Modulator for Cancer Therapy.

Sun H, Chen D, Zhan S, Wu W, Xu H, Luo C, Su H, Feng Y, Shao W, Wan A, Zhou B, Wan G*, Bu X*.

J Med Chem. 2020 Oct 8;63(19):11286-11301.·2020·DOI

Wan Lab authors: 万国辉, 詹偲悦

New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection.

Yan S, Sun H, Bu X*, Wan G*.

Front Pharmacol. 2020 Jun 12;11:912.·2020·DOI

Wan Lab authors: 万国辉, 严时佳

RNA m6 A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy.

Lin Z, Niu Y, Wan A, Chen D, Liang H, Chen X, Sun L, Zhan S, Chen L, Cheng C, Zhang X, Bu X, He W*, Wan G*.

EMBO J. 2020 Jun 17;39(12):e103181.·2020·DOI

Wan Lab authors: 万国辉, 梁衡, 牛艺, 林子又, 孙蕾, 詹偲悦

Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events.

Feng Y, Su H, Li Y, Luo C, Xu H, Wang Y, Sun H, Wan G, Zhou B, Bu X*.

Chem Commun (Camb). 2020 Mar 5;56(19):2881-2884.·2020·DOI

Wan Lab authors: 万国辉

Mechanism of aberrant long non-coding RNA expression in an adriamycin-resistant liver cancer cell strain.

Wang Y, Wan G, Wang H, Zhang G, Li Z, Lu L, Wu Y, Yu X, Du J*.

Dig Liver Dis. 2020 May;52(5):582-587.·2020·DOI

Wan Lab authors: 万国辉

The mechanism and research progress of drug resistance of PD-1/PD-L1 immunotherapy in tumors

Yan S, Sun L, Wan G*.

Acta Pharm Sin. 2019, 54(10): 1728-1734·2019·DOI

Wan Lab authors: 万国辉, 严时佳, 孙蕾

Review on clinical research progress of immunotherapy in liver cancer

Yan S, Liu X, Wan G*.

Acta Pharm Sin. 2019, 54(10): 1749-1754·2019·DOI

Wan Lab authors: 万国辉, 严时佳

Nodal Facilitates Differentiation of Fibroblasts to Cancer-Associated Fibroblasts that Support Tumor Growth in Melanoma and Colorectal Cancer.

Li Z, Zhang J, Zhou J, Lu L, Wang H, Zhang G, Wan G, Cai S, Du J*.

Cells. 2019 Jun 4;8(6):538.·2019·DOI

Wan Lab authors: 万国辉

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.

Niu Y, Lin Z, Wan A, Chen H, Liang H, Sun L, Wang Y, Li X, Xiong XF, Wei B*, Wu X*, Wan G*.

Mol Cancer. 2019 Mar 28;18(1):46.·2019·DOI

Wan Lab authors: 万国辉, 梁衡, 牛艺, 林子又, 孙蕾

N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development.🗍

Niu Y, Wan A, Lin Z, Lu X, Wan G*.

Acta Pharm Sin B. 2018 Oct;8(6):833-843.·2018·DOI

Wan Lab authors: 万国辉, 牛艺, 林子又

AP-1 confers resistance to anti-cancer therapy by activating XIAP. 

Wang Y, Wan GH, Wu YM, Wang HS, Wang HF, Zhang G, Lu LL, Li ZQ, Chan KY, Zhou Y, Cai SH, Qi YF, Du J*.

Oncotarget. 2018 Jan 3;9(18):14124-14137.·2018·DOI

Wan Lab authors: 万国辉